Abuse is one of the most famous "run and gun" video games, and 4MAbuse is a very small LiveCD, which boots directly to this game.
If you are going to run 4MAbuse in VirtualBox, then make sure that Pointing Device (in System Settings) is setup to PS/2 Mouse.
1) Boot your copy of 4MAbuse:
2) The game will be started automatically:
4MLinux will try to load dedicated display drivers for your video card. But if your GPU is unsupported, 2D drivers will be used instead.
3) When you quit Abuse, alsamixer will be opened (to enable you to adjust the sound volumes):
Just press the Escape button to return to Abuse.
Have fun :-)